Sean Longstaff has also long suffered an ankle injury in training, although Andy Carroll is close to your return for Newcastle, says head coach Steve Bruce.
After recovering from a knee injury which kept him out of the final stages of their previous effort, longstaff has played all four Premier League games so far this season.
The 21-year-old drawn interest from Manchester United in the summer after his impressive performances from his breakthrough year, but Bruce confirmed he’s been sidelined because of an injury in training.
Bruce explained:”Regrettably, Sean Longstaff turned an ankle yesterday in training. Tomorrow, he won’t make.
“He tried to obstruct a cross and unfortunately twisted his arm and we will not know how intense that’s till another few days. That is a bit of a blow for us.
“It’s one of the freak ones that sadly happens. We were frustrated for him that we’ve lost a player to a freak accident. That is what happens in football regrettably.”
Newcastle started the year poorly with defeats Arsenal and Norwich, but rallied to get a shock win in Tottenham due to the objective of Joelinton.
The striker has not faced competition for his place in the side however he could be challenged.
Bruce stated:”[Carroll has] made big progress this week. He is thrilled with how it’s gone so far. It is good news for us.
“I really think for everyone to watch him associating with instruction was good for him, good for your group of course and also people want now some good news from his or her professional.
“It’s always quite difficult to put timescale on somebody like Andy, he’s fit when he’s fit. He’s joined in, he has worked hard, there is a grin across his face that this morning at which he is comfortable which is great.
“When you’ve got a ankle like he has got, it’s always the response to the job he’s put in. In the moment it’s all very good.”
Newcastle face a visit because they seem like the first group to accumulate points out of the side of Jurgen Klopp this year, and Bruce admits it will be a very difficult challenge.
He added:”We are going to European champions who haven’t lost a game at home for two and a half years.
“They’re as good a group as you’re going to play against so we will have to defend well that is for sure. But we must take part and show that resilience such as we did against Spurs.
“When we have got it, can we trigger a hazard and that has got to be the game plan straight away again.
“it is a great scene with a wonderful service, a major club, large history, large tradition. For me personally always likely to be among the highlights because they are rather unique in what they’ve done through the years in their background, to go there and perform them is.
“I’ve always just loved it. From the big games it’s crucial that you just love it, that’s exactly what were inside for. It couldn’t be anymore difficult because they are a very, very good team now.”